Data · dataset · 2026
Vasogenic bloodborne progenitors and diabetes
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32630844.v1
Diabetes Mellitus (DM) is a group of metabolic disorders which lead to chronic hyperglycaemia.
Description
Across all age groups worldwide, the prevalence of DM was recently estimated to be at 2.8% but with an expected rise to 4.4% by the year 2030. Long-term DM carries the significant risk of developing complications, in particular, those which affect the vascular system, such as diabetic nephropathy, neuropathy and retinopathy.
Of these, diabetic retinopathy (DR) is the most common, and it remains a leading cause of vision loss in adults between the ages of 20-74.<br><br>Underlying these vasodegenerative pathologies is a complex pathogenesis leading to progressive closure of capillaries in the affected organs and results in non-perfusion, attributed to a dysfunction of reparative cells called Endothelial Progenitor Cells (EPCs). EPC is an umbrella term applied to three distinct populations of vasoactive progenitors which contribute to adult (postnatal) angiogenesis in different ways.
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The circulating EPC can be identified via flow cytometry from peripheral blood mononuclear cells (PBMC5),<br>and serves as a measure of angiogenic potential. Myeloid Angiogenic Cells (MACs) are pro-angiogenic macrophages. Endothelial Colony Forming Cells (ECFCs) are the de facto endothelial progenitor, contributing directly to vascular repair.<br><br>In this PhD project, it was hypothesised that all three classes of EPCs are altered in the context of diabetes.
EPCs from patients with diabetes have reduced expression of CD31, suggesting an impairment in angiogenic function. Furthermore, ECFC5 isolated from these patients were also found to show impaired angiogenic function compared to those isolated from non-diabetic controls. MACs isolated from patients with proliferative diabetic retinopathy (PDR) were found to have heterogeneous pro-angiogenic gene expression, suggesting different classes of the condition.
Overall, these results show that each player in the angiogenic machinery is altered in some capacity in response to diabetic conditions.
Links
Where it is published
- DOI doi.org/10.17034/32630844.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 4 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32630844 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32630844 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32630844 | 11 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32630844 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |