Data · dataset · 2024
Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague–Dawley rats
Listed in ScienceDB
In this study, we used different types of carbon materials, namely, graphene oxide (GO), single-walled carbon nanotubes (SWCNTs), and multiwalled carbon nanotubes (MWCNTs), as models to observe their distribution and oxidative damage in vivo.
Description
The results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these nanomaterials. SR-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the brain.
This shows that the three types of carbon-based nanomaterials could cross the gas–blood barrier and eventually reach the liver tissue. In addition, SWCNTs and MWCNTs could cross the blood–brain barrier and accumulate in the cerebral cortex. The increase in ROS and MDA levels and the decrease in GSH, SOD, and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the liver.
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This suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS generation. In addition, iron (Fe) contaminants in these nanomaterials were a definite source of free radicals. However, these nanomaterials did not cause obvious damage to the rat brain tissue.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.j00186.00112 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Nanotechnology 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.j00186.00112 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:4018 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |