Data · dataset · 2026
<p><i>unc-103</i>(G427R) is a gain-of-function allele that inhibits egg laying.</p>
Listed in UCL Research Data Repository
<p>(<b>A</b>) Amino acid sequence alignment of the CNBHDs from mEAG1, EGL-2, hERG, and UNC-103.
Description
Secondary structure elements from the mEAG1 CNBHD (PDB: 4F8A) are indicated above the alignment, with three α-helices (αA–αC) and nine β-strands (β1–β9) indicated by coils and arrows, respectively. The red star indicates the conserved glycine residue corresponding to mEAG1(G588), EGL-2(G574), UNC-103(G427), and hERG1a(G749).
(<b>B-C</b>) Representative brightfield images and quantification of the eggs retained in the uterus of adult animals with the indicated genotypes. <i>gof</i>, gain-of-function; <i>lof</i>, loss-of-function. White asterisks mark the vulva position. (B) A, anterior; D, dorsal.
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Scale bar, 50 μm. (C) Numbers shown on the bars indicate the total number of animals scored for each genotype. Mean ± SEM are shown. ****, p < 0.0001.
One-way ANOVA with Dunnett’s multiple-comparisons test for comparing each mutant genotype with wild type.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pgen.1012255.g007 ↗
DOI / persistent id · from rdr ucl ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from rdr ucl ac uk
Topics
- From keywords
- Biochemistry and cell biology · Caenorhabditis elegans · Cancer · Earth & Environmental Science · Genetics · Life Sciences · Medicine & Health
- Inferred from text
- Image 65%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UCL Research Data Repository | oai:figshare.com:article/34049542 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3101 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · rdr ucl ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:6239 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['caenorhabditis elegans </'] |
| description | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| title | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/title |