Short-course aminoglycosides as adjunctive treatment in adults with sepsis (SAGA) - a cluster-randomized trial

Nine acute care hospitals were randomized to preferred empirical treatment of patients hospitalized with sepsis with either ceftriaxone or cefuroxime monotherapy (monotherapy arm; four hospitals) or cefuroxim combined with an aminoglycoside (combination arm; five hospitals). The primary outcome was 30-day all-cause mortality.

The aim was to cross-over to the alternative intervention after one year. However, the trial was prematurely terminated to due non-compliance with the combination arm and low recruitment rates.