Screening miRNA biomarkers for postmenopausal osteoporosis based on bioinformatics methods

Finally, the diagnostic efficacy of miRNA was evaluated using ROC curves, the target genes of miRNA were predicted using a database, and functional enrichment of the target genes was performed using Metascape.Results miR-223-3p has a high predictive diagnostic value for PMO. GO and KEGG enrichment analysis was conducted on 34 target genes potentially regulated by miR-223-3p, and the results showed that multiple pathways were associated with bone development.Conclusion miR-223-3p has significance in the diagnosis of PMO and may regulate bone development by regulating downstream target genes.