Data Sheet 1_Associations between inflammatory-lipid indices and clinical outcomes in ischemic stroke patients treated with mechanical thrombectomy.docx

We conducted a comprehensive analysis of six common inflammatory-lipid indices to evaluate the associations between these indices and four clinical outcomes after mechanical thrombectomy (MT) for acute ischemic stroke (AIS), and to identify generalizable consistently associated markers for all four clinical outcomes.</p>Methods<p>In this retrospective studyassociations between inflammatory-lipid indices, namely monocyte-to-high-density lipoprotein cholesterol ratio (MHR), platelet-to-HDL-C ratio (PHR), neutrophil-to-HDL-C (NHR), lymphocyte-to-HDL-C ratio (LHR), fibrinogen-to-HDL-C ratio (FHR), and C-reactive protein-to-HDL-C ratio (CRP/HDL-C), and four post-MT clinical outcomes comprised hemorrhagic transformation (HT), malignant cerebral edema (MCE) 90-day unfavorable outcome and all-cause mortality were evaluated using multivariable analyses.

False discovery rate (FDR) correction was applied for multiple comparisons. NHR, which demonstrated consistent significance for all four clinical outcomes, was subjected to further analyses.</p>Results<p>A total of 513 patients were included., demonstrated The incidences of HT, MCE, unfavorable outcome, and all-cause mortality were 30.6% (157), 22.6% (116), 54.8% (281), and 25.9% (133), respectively. The NHR was significantly associated with all four clinical outcomes (HT: odds ratio [OR] 1.079, 95% confidence interval [CI] 1.023–1.142, p-FDR = 0.034; MCE: OR 1.089, 95% CI 1.031–1.154, p-FDR = 0.008; unfavorable outcome: OR 1.177, 95% CI 1.098–1.269, p-FDR < 0.001; all-cause mortality: hazard ratio [HR] 1.047, 95% CI 1.012–1.084, p-FDR = 0.022).