Significantly enriched GO terms in heart jogging genes in zebrafish and their human and mouse orthologs

Mouse data: GO terms significantly enriched in mouse orthologs of zebrafish ‘heart jogging’ genes. The GO biological process, molecular function and cellular component terms that are highly enriched in the mouse ‘jogging ortholog’ gene list. The GO terms are listed in order of decreasing p-values and the ‘universe set’ size included in the functional analysis using VLAD is 24,813.

Biological process summary: Summary of all enriched biological process GO terms across all three species. The enriched biological process GO terms are grouped into general biological areas (‘development’, ‘patterning’, ‘cellular process’, ‘signaling’, ‘movement’ and ‘high level terms’, text in upper case). Each area is subdivided into more specific ontologies, based on the Gene Ontology structure.

A subset of the biological process GO terms and data are reported in Table 2 in the main article. High-level terms were not included in any further discussion, as these terms are not specific enough to be informative. k: the number of genes in each gene list annotated to the GO term; M: the number of genes in the species proteome annotated to the GO term. Starred genes are annotated directly to the enriched term.

Non-starred genes are annotated to a ‘child’ of the enriched term. DAR: zebrafish, HUM: human, MUS: mouse. Mouse gene list:‘Early heart development’ mouse gene list.

The evidence that these 103 mouse genes have a role in the early stages of heart development comes from their orthology to the zebrafish ‘heart jogging’ gene list, from phenotypes associated with specific genotypes, or annotation to the GO term ‘determination of heart left/right asymmetry’ or it’s child terms (see method section in main article for full details).