Constarium
← Search

Data · dataset · 2026

Fused deposition modelling three-dimensional printing of solid dosage forms

Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32631534.v1

Three-dimensional printing (3DP) is a widely used technique for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing.

Description

Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various internal structures and the ability to introduce multiple specific functionalities.

This thesis’s main aim was to understand printability in FDM-3DP and the factors influencing it, as well as to manufacture novel gastro-retentive floating drug delivery systems through FDM-3DP using pharmaceutical excipients. Hot-melt extrusion (HME) was implemented to fabricate filaments with adequate properties for FDM-3DP. Rheological, mechanical and physical characterisation of filaments were evaluated to provide information on the impact of these properties on the FDM 3DP process.

Read the rest (2 more)

Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time.

Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.<br><br><i>Thesis embargoed until 31 December 2026</i>.<br>

Links

Where it is published

Catalogue records · 1

Topics

From keywords
Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Non-Newtonian fluid flows · Non-Newtonian fluid flows · Non-Newtonian fluid flows · Non-Newtonian fluid flows
Provenance · 4 source records, 13 field assertions
SourceKeyLast seenRaw
ZivaHuboai:figshare.com:article/326315347 d agoJSON v1
Deakin Research Onlineoai:figshare.com:article/326315347 d agoJSON v1
DMU Figshareoai:figshare.com:article/326315347 d agoJSON v1
UCL Research Data Repositoryoai:figshare.com:article/326315347 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].anzsrc:field:401212mapping · rdr ucl ac ukvocabulary-mapper@1.0.0keywords['rheology']
concepts[field].anzsrc:field:401212mapping · zivahub uct ac zavocabulary-mapper@1.0.0keywords['rheology']
concepts[field].anzsrc:field:401212mapping · dro deakin edu auvocabulary-mapper@1.0.0keywords['rheology']
concepts[field].anzsrc:field:401212mapping · figshare dmu ac ukvocabulary-mapper@1.0.0keywords['rheology']
concepts[field].local:field:earth-environmentalmapping · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].local:field:earth-environmentalmapping · dro deakin edu auconnector:dro_deakin_edu_au@1.0.0
concepts[field].local:field:earth-environmentalmapping · rdr ucl ac ukconnector:rdr_ucl_ac_uk@1.0.0
concepts[field].local:field:earth-environmentalmapping · figshare dmu ac ukconnector:figshare_dmu_ac_uk@1.0.0
descriptionsource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0/metadata/dc/description
license_textsource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
publication_datesource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
titlesource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0/metadata/dc/title