Data · dataset · 2026
Research Protocol for m6A Modification-Related Molecular Mechanisms in Type 2 Diabetes Mellitus (T2DM) and Experimental Validation
Listed in ScienceDB
This study focuses on Type 2 Diabetes Mellitus (T2DM) and conducts multi-dimensional research centered on m6A modification.
Description
Firstly, through bioinformatics analysis of GEO datasets, diabetes gene chips/MeRIP-seq chips, and verification with cross-databases, the expression, correlation, and differential genes of m6A-related enzymes are analyzed. Secondly, signaling pathways such as PI3K-AKT are screened via GO/KEGG enrichment analysis and network pharmacology.
Meanwhile, a T2DM rat model is established to perform animal experiments, verifying changes in indicators, genes, and proteins after treatment. Combined with molecular docking and other experiments, this study ultimately clarifies the regulatory mechanism of m6A modification in T2DM.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.xbyxb.00171 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Bioinformatics and computational biology 69%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.xbyxb.00171 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:group:3102 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (69%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |