Supplementary file 1_The prevalence of Brugada syndrome in patients presenting to an emergency room in Riyadh, Saudi Arabia.pdf

BrS was diagnosed when a type 1 BrP was observed with no secondary causes, and BrP was diagnosed when a non-type 1 pattern was observed. A prespecified sensitivity analysis was conducted, excluding patients whose presentation was potentially compatible with BrS (syncope, presyncope, cardiac arrest, and palpitations).</p>Results<p>We included 1,000 patients. Men constituted 498 patients (49.8%).

The majority were Saudi nationals (830, 85.6%) and the overall median age was 46 years (IQR: 30–65 years). The majority of the patients were afebrile at presentation (915, 93%) and a small number of patients took Brugada-inducing medications (27, 2.7%). The prevalence of BrS was 2/1,000 (0.002; 95% CI: 0.0002–0.007) and the prevalence of BrP was 26/1,000 (0.026; 95% CI: 0.0179–0.0390).

Among the patients with BrP, 11 exhibited a type 2 pattern (42.3%) and 15 exhibited a type 3 pattern (57.7%). The sensitivity analysis revealed a prevalence of BrS of 2/912 (0.002; 95% CI: 0.0–0.0061) and a prevalence of BrP of 26/912 (0.028; 95% CI: 0.0178–0.0402).</p>Conclusion<p>This is the first Saudi Arabian study on BrS prevalence, suggesting a high prevalence and a notable proportion of non-type 1 Brugada electrocardiogram (ECG) patterns.</p>