Simultaneous Quantification of Lanthanoid Ions in Solution by Magnetic Anisotropy-Assisted ¹⁹F NMR

Here, we designed and synthesized two chemical-magnetic probes (CF₃-TDA and F-TDA), each containing a ¹⁹F reporter and metal chelating moiety, for simultaneous discrimination and quantification of Ln³⁺ ions in solution thanks to the distinct magnetic anisotropy of Ln³⁺ ions. These probes form stable lanthanoid complexes, generating well-resolved ¹⁹F NMR chemical shifts induced by the distinct magnetic anisotropy of Ln³⁺.

This strategy enables the simultaneous identification and quantification of individual Ln³⁺ in mixtures, even in the presence of competing common metal ions. This approach combines the metal-chelating property and distinct magnetic anisotropy for lanthanoid ion quantification by NMR. It provides a conceptually innovative and broadly applicable platform for precise lanthanoid assays, facilitating the monitoring of critical elements in industrial and strategic contexts.