Functionalised porous organic polymers for delivery of bioactive nitric oxide for potential therapeutic applications

In addition, by substituting different monomers a variation in the BET surface area and pore volumes was achieved. Following PSM the NO release was determined in response to external stimuli and the rate of NO release and total NO released from each functionalised polymer was determined via the Griess method, and results were analysed based on porosity, NO-donor functional group and core chemical structure.<br><br>Key findings have shown that polyamide-based /V-diazeniumdiolates demonstrate considerable potential as NO-donors, as some released over 1600 pmol g^f NO; as amide /V-diazeniumdiolates have received minimal attention in the literature, this indicates a great undiscovered potential.

Amides show more potential as /V-diazeniumdiolate NO-donors compared to /V-nitroso NO-donors, and the presence of amide and amine groups can enhance NO release from /V-nitroso based NO-donors. In this work, the synthesised N- nitroso polymers demonstrated NO release capacities ranging 1.9 pmol g_1to 277.0 pmol g1 and the /V-diazeniumdiolate polymers demonstrated NO release capacities ranging 50.8 pmol g1 to 1616.4 pmol g1.

The main factors determining NO release capacity of the polymers was the type of NO-donor and core chemical structure. Other key findings include demonstrated controllable NO release of /V-nitroso based NO-donors, by control of UV irradiation trigger, and control over NO release by varying pore size. Using these findings can help to direct future design of novel NO-donors for potential therapeutic applications.<br>