Omics · study · 2026
Effect of Rv3574, Rv0047c and Rv0602c overexpression on gene expression under ATc induction in Mycobacterium smegmatis [batch 2]
Listed in NCBI GEO
transcriptional regulation on DNA damage response is essential for persistence and mutagenesis of Mtb.
Description
Rv3574, Rv0047c and Rv0602c are conducted as control regulators with comparison to Rv2282c, Rv1990c and Rv1985c. We here report Rv3574, Rv0047c and Rv0602c inhibit cell division but show no influence on DNA damage response system compared to Rv2282c, Rv1990c and Rv1985c.
Overexpression of Rv3574, Rv0047c and Rv0602c does not influence the expression of genes related to oxidative stress. Complemention of tpx does not relieve the effect of Rv3574, Rv0047c and Rv0602c. Taken together, our study provides a conceptual framework for understanding how mycobacteria orchestrate the complex DDR system through redox-based transcriptional regulation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327827 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327827 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1452870 ncbi.nlm.nih.gov/bioproject/PRJNA1452870 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Genetics 69%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327827 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |