Acute Slow Oscillation Power After Photothrombotic Stroke Wide-Field Calcium Imaging, Behavioral, and Histological Dataset

Each mouse was assessed at three experimental timepoints: baseline (pre-stroke), acute (24 hours post-PT stroke), and chronic (one week post-PT stroke), with histology collected only at the post-chronic endpoint. The dataset is hierarchically organized under a top-level /data directory containing three primary modality folders: /behavior, /WFCI, and /histology. The /behavior folder is organized by mouse ID (e.g., /M01) and then by timepoint (/bsl, /acute, /weekone), containing raw video recordings, Excel-format scoring sheets, and aggregated GraphPad Prism files summarizing results across all animals.

The /WFCI folder is subdivided into three processing tiers — /Raw (unprocessed imaging files), /Tier1_Derived (intermediate processed data), and /Tier2_SourceData (analysis-ready outputs organized by mouse and timepoint) — supporting reproducibility from raw acquisition through final analysis. The /histology folder contains two subfolders, /cresyl_violet and /IHC, holding stained tissue section images. File formats include TIFF images for histology, CSV and XLSX for behavioral scoring, and standard video formats for raw behavior recordings.

The organizational rationale — mouse ID → modality → timepoint — enables straightforward longitudinal comparisons within subjects and cross-sectional comparisons across the cohort. Data were generated by Jake Lee and Arnav Ajay Jadav in the Landsness Lab, Department of Neurology, Washington University in St. Louis (contact: jake.l@wustl.edu), and are suitable for analyses of stroke-induced changes in cortical dynamics, motor behavior, and structural pathology.