Data · dataset · 2025
Three Distinct Clinical Phenotypes of Immune Checkpoint Inhibitor-Induced Bullous Pemphigoid Predict Divergent Treatment Responses and Outcomes
Listed in Teesside University Research Data Repository
Figure S1.
Description
Nodular-erosive type: Firm, dark brown to skin-colored nodules with characteristic surface ulcerations and crusting on the lower extremities. Figure S2.
Therapeutic approach distribution among ICI-BP subtypes Stacked bars show the distribution of treatment strategies across ICI-BP phenotypes. The Bullous type was most commonly managed with systemic glucocorticoid (GC) monotherapy (80.0%). The Edematous erythema-bullous type more often used early combination therapy, including GC plus methotrexate (MTX) (55.6%) and GC plus MTX plus intravenous immunoglobulin (IVIG) (22.2%).
Read the rest (3 more)
The Nodular-erosive type showed an intermediate pattern, with GC monotherapy in 75.0% and GC plus MTX plus IVIG in 25.0%. Abbreviations: ICI-BP, immune checkpoint inhibitor-induced bullous pemphigoid; EEB, Edematous erythema-bullous; GC, glucocorticoid; MTX, methotrexate; IVIG, intravenous immunoglobulin. Figure S3.
Initial steroid dose across phenotypes and disease groups. (A) Mean initial inpatient methylprednisolone dose (highest single-day; mg) across groups: sBP (30 mg), Bullous type (30 mg), Edematous erythema-bullous type (48 mg), and Nodular-erosive type (43 mg). (B) Comparison of mean initial inpatient methylprednisolone dose (highest single-day; mg) between ICI-BP and sBP.
The Edematous erythema-bullous plus Nodular-erosive phenotypes used a higher mean initial dose than sBP (40 mg vs 30 mg; P = .045). Abbreviations: ICI-BP, immune checkpoint inhibitor-induced bullous pemphigoid; sBP, spontaneous bullous pemphigoid; EEB, Edematous erythema-bullous.
Links
Where it is published
- DOI doi.org/10.17632/vpmcrfx3y8.3 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Dermatology · Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Disease 75%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/vpmcrfx3y8.3 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:320205 | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['Dermatology'] |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |