Longitudinal urinary 8-oxoGuo as a potential biomarker of persistent risk during ICU and post-ICU hospitalization

Associations were similar when APACHE II replaced SOFA, whereas longitudinal 8-oxodGuo showed no consistent associations. Adding baseline 8-oxoGuo to SOFA increased the area under the curve for 90-day mortality from 0.669 to 0.719 (<i>p</i> = 0.046), while incorporating longitudinal trajectory information increased the area under the curve for mortality after ICU discharge from 0.682 to 0.741 (<i>p</i> = 0.029). Overall, these findings indicate that higher longitudinal urinary 8-oxoGuo is associated with adverse outcomes across ICU and post-ICU hospitalization and provides incremental prognostic discrimination beyond baseline SOFA.</p> <p></p><p>Serial urinary 8-oxoGuo tracked mortality risk beyond ICU discharge.</p><p>8-oxoGuo trajectories improved post-ICU mortality discrimination beyond SOFA.</p><p>Urinary RNA, but not DNA, oxidation showed consistent prognostic associations.</p><p></p> <p>Serial urinary 8-oxoGuo tracked mortality risk beyond ICU discharge.</p> <p>8-oxoGuo trajectories improved post-ICU mortality discrimination beyond SOFA.</p> <p>Urinary RNA, but not DNA, oxidation showed consistent prognostic associations.</p>