Table · dataset · 2026
Macrophage-Inspired Fe<sub>3</sub>O<sub>4</sub> Nanozymes with a Hydrophobic Spiky Topography for Treating Drug-Resistant Bacteria
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Fe<sub>3</sub>O<sub>4</sub>, the first reported nanozyme and the first FDA-approved transition-metal-based nanomaterial, holds promise for antibacterial therapy but is limited by poor ROS catalytic activity and utilization.
Description
Inspired by macrophage-like bacterial capture and insect wing micro/nanostructures, we designed Fe<sub>3</sub>O<sub>4</sub> nanoparticles encapsulated in a conductive, hydrophobic carbon shell with densely aligned nanoneedles.
This architecture shifted the Fe/O d/p-band centers toward the Fermi level, promoted H<sub>2</sub>O<sub>2</sub> adsorption and activation, and strengthened H<sub>2</sub>O<sub>2</sub> homolysis through H<sub>2</sub>O<sub>2</sub>–O hydrogen bonding, yielding 2.67-fold higher POD-like activity than that of pristine Fe<sub>3</sub>O<sub>4</sub>. The hydrophobic nanoneedle surface further inhibited continuous liquid film formation, enhanced bacterial adhesion, and shortened the distance between ROS generation sites and bacterial membranes, thereby improving ROS utilization.
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Consequently, the engineered Fe<sub>3</sub>O<sub>4</sub> nanozyme achieved an MRSA inhibitory concentration nearly 15-fold lower than pristine Fe<sub>3</sub>O<sub>4</sub>. This work offers a microenvironment engineering strategy to advance Fe<sub>3</sub>O<sub>4</sub>-based antibacterial nanozymes toward clinical translation.
Links
Where it is published
- DOI doi.org/10.1021/acs.nanolett.6c02274.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
Provenance · 1 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33952454 | 12 d ago | JSON v1 |
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| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |