Data for: TARGETING HIGHER LEVELS OF LACTATE IN THE POST-INJURY PERIOD FOLLOWING TRAUMATIC BRAIN INJURY

We found the highest plasma lactate levels in the patients with the post-injury period following moderate TBI as compared to controls (p=0.0047, t=2.924, 95% CI -0.2154 to -0.04071) where the median lactate level was 0.832±0.033 and 0,704±0.021 mmol/L in controls. No significant differences were seen between mild and moderate post-TBI (p=0.079; t=1.772); significant difference was also seen between general post-TBI group versus controls (p=0.0181; t=2.396; 95% CI -0.1627 to -0.01551) with the median of total lactate level 0.793±0.019 mmol/L. Lactate data did not distinguish with the respect to gender and age.

The results showed no significant differences in tau protein, pyruvate, lactate dehydrogenase and ceruloplasmin levels. We didn’t find elevated tau protein levels in the serum samples of the patients from the general clinical group as compared to controls (p=0.0897, t=1.710; 95% CI -1.27 to 18.19) and in this patient group the median of total tau level was 79.57±24.41 pg/ml and 71.14±20.56 pg/ml, in controls. Conclusion: The study shows data, revealing higher lactate levels in the post-injury period following TBI that reflect post-injury oxidative dysmetabolism and are more expressed in the post-injury period following moderate TBI.