Plk1 gene regulatory network involved in genomic instability

Previous studies found the gene Plk1 as a candidate for genomic instability; however, the mechanisms by which the gene and its dysregulation could induce genomic instability events weren’t entirely clear.

Therefore, to elucidate the mechanisms, gene circuits, and proteins involved in the genomic instability events promoted by Plk1, a novel approach that involved the reconstruction and modeling of the regulatory network of Plk1 was adopted. The network contains nine processes where Plk1 participates that are involved in maintaining the stability of the genome. Subsequently, mathematical modeling of the regulation network was carried out under a mass action law kinetic approximation to generate a model with 1030 reactions and 716 biological species.