Data Sheet 1_Circulating and cerebrospinal fluid soluble TREM2 levels and risk of perioperative neurocognitive disorders in surgical patients: a systematic review and meta-analysis.zip

Heterogeneity was assessed via I². Subgroup and sensitivity analyses were performed. PROSPERO: CRD420261386903.</p>Results<p>Eight studies (1,154 patients) were included; seven with quantitative data (1,072 patients) were meta-analyzed.

Patients with PND had higher sTREM2 levels than controls (SMD = 0.44, 95% CI: 0.02 to 0.87, p = 0.040; I² = 86.5%). Subgroup analyses showed a positive direction of effect in CSF (SMD = 0.61, 95% CI: −0.02 to 1.23) but not in peripheral blood (SMD = 0.18, 95% CI: −0.13 to 0.49). Leave-one-out sensitivity analysis showed that the pooled estimate became non-significant after excluding the largest study, warranting cautious interpretation.

One additional study reported that postoperative CSF sTREM2 elevation independently predicted POCD (adjusted OR = 1.07, 95% CI: 1.01–1.13).</p>Conclusion<p>Elevated perioperative sTREM2 concentrations in cerebrospinal fluid, but not in peripheral blood, showed a modest positive association with PND risk. sTREM2 represents a candidate biomarker for perioperative cognitive complications; however, the very low certainty of the underlying evidence precludes definitive conclusions.

Large-scale standardized studies are needed to validate its clinical utility.</p>Systematic review registration<p>The systematic review was prospectively registered in PROSPERO (Unique Identifier: CRD420261386903), crd.york.ac.uk/prospero/.</p>