Electrostatic Induction-Regulated γ-Ray Radiation Polymerization of Iq-IA-AA Asymmetric Adhesive Hydrogel: Preparation and Properties

The moist and dynamic physiological environment of the oral cavity limits the retention and efficiency of locally administered therapeutic drugs, posing challenges to the clinical local intervention of OUs. In this study, γ-ray radiation polymerization technology was used to prepare an asymmetric hydrogel material (Iq-IA-AA) based on electrostatic interaction-induced phase separation.

During the polymerization process, the polarity of the reaction system was regulated by the ratio of ethanol/water binary solvent. Itaconic acid (IA) and acrylic acid (AA) monomers rich in carboxyl groups were directionally introduced into the upper surface of the hydrogel to enhance mucosal adhesion; meanwhile, ionic liquid (Iq) monomers containing long hydrophobic carbon chains and double bonds settled to the bottom through phase separation polymerization to form a non-adhesive surface, thus constructing an asymmetric adhesive bilayer structure.