Omics · study · 2026
Investigation of the impact of Arylsulfatase L (ARSL) deletion in rat chondrosarcoma (RCS) cell lines
Listed in NCBI GEO
In this study, we identified arylsulfatase L (ARSL), which is mutated in X-linked chondrodysplasia punctata (CDPX), as a Golgi-localized enzyme responsible for glycosaminoglycan (GAG) desulfation.
Description
To elucidate the cellular and molecular consequences of ARSL deficiency, we performed trasncriptome profiling using RNA-sequencing (RNA-seq) in rat chondrosarcoma (RCS) wild-type (WT) and ARSL knockout (KO) cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301703 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301703 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1287369 ncbi.nlm.nih.gov/bioproject/PRJNA1287369 ↗
project · from NCBI GEO
- PubMed 42103217 pubmed.ncbi.nlm.nih.gov/42103217 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301703 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |