Data Sheet 1_Identifying dietary and daily product-use patterns explaining joint variation in multiple urinary phthalate metabolites via sparse reduced-rank regression.docx

Sparse reduced-rank regression was used to identify latent patterns of dietary consumption, food-contact material use, and consumer product use jointly associated with the eight metabolite levels after covariates adjustment, and analyses were repeated by sex.</p>Results<p>A single latent pattern was identified, in which all phthalate metabolites showed positive loadings (+0.10 to +0.46). Mineral spring water (+0.08), grains (+0.08), tap water (+0.06), and beverages in plastic pouches (+0.08) exhibited the largest loadings in the same direction as the phthalate metabolites.

In sex-stratified analyses, drinking water and grain consumption among men and the use of beverages in plastic pouches and makeup products among women showed prominent loadings in the same direction as the eight metabolites.</p>Conclusion<p>Consumption of mineral spring water, tap water, grains, and beverages in plastic pouches were major dietary and daily product use factors associated with higher urinary phthalate metabolite mixtures in Korean adults.

Given that current Korean regulations cover a limited subset of phthalates at levels less stringent than international standards, expanding regulatory frameworks for drinking water and food-contact materials and adopting precautionary lifestyle measures are warranted, along with prospective studies to clarify source-specific causal pathways.</p>