Data · collection · 2015
Luteolin attenuate the d-galactose-induced renal damage by attenuation of oxidative stress and inflammation
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Luteolin is reported to have antioxidant and anti-inflammatory properties.
Description
In this study, we investigated the protective effect of luteolin against the renal damage induced by d-galactose (d-gal). The levels of creatinine (Cr) and urea nitrogen (BUN) were evaluated in plasma, kidney sections were stained with haematoxylin–eosin, followed by assessment of the antioxidant and anti-inflammatory activity.
Furthermore, we also investigated the expression of the p38 mitogen-activated protein kinase (p38 MAPK) and its phosphorylated activation. The results of luteolin treatment showed that the renal damages were attenuated. Luteolin could significantly ameliorate d-gal-induced oxidative damage and suppress the inflammatory response.
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Moreover, the result also shows that luteolin could significantly inhibit the p38 MAPK phosphorylation in the kidneys from the model of d-gal-treated mice. Therefore, our research suggests that luteolin might be involved in the attenuated oxidative stress and inflammatory responses, hence the protective effects against d-gal-induced renal damage.
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Where it is published
- Repository landing page tandf.figshare.com/collections/Luteolin_attenuate_the_d_galactose_induced_renal_d… ↗
landing page · from DataCite
- Repository landing page tandf.figshare.com/collections/Luteolin_attenuate_the_d_galactose_induced_renal_d… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2033576.v1 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2033576 ↗
DOI / persistent id · from DataCite
Documentation and papers
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2033576 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2033576.v1 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2033576 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2033576.v1 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Biological sciences · Biological sciences · Clinical medicine · Clinical medicine
- From keywords
- Chemistry · Chemistry · Ecology · Immunology · Life Sciences · Life Sciences · Research, science and technology policy
Provenance · 2 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.2033576 | 10 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.c.2033576.v1 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Chemistry'] |
| concepts[field].local:field:chemistry | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Chemistry'] |
| concepts[field].local:field:life-sciences | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Biological Sciences'] |
| concepts[field].local:field:life-sciences | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Biological Sciences'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |