Multiomic analysis of equine aging-related osteoarthritis highlights gut microbiome and metabolomic alternations

Mounting evidence in humans and laboratory species indicates both systemic and local inflammation play a role in OA pathogenesis, with increasing recognition that the gut microbiome contributes to a pro-inflammatory state. However, the role of the gut-joint-axis has not been fully explored in etiopathogenesis of equine OA.

Therefore, the aim was to investigate fecal and leukocyte microbiome profiles and host gene expression patterns in horses with naturally occurring aging-related OA compared to controls.