Deep Invaginations of Nuclear Envelope Coordinate Spatial Organization of Chromatin in Epithelium (Part A: 7d and 2h grown epithelium)

Here, we describe deep invaginations of the nuclear envelope (DINEs) as common features of epithelial cell nuclei. Our data indicates DINEs in mature epithelium in vitro and in vivo.

Our mRNAseq data compiles transcriptional profiling of these DINE-containing, mature epithelium grown for 7 d, and epithelial cells grown for 7 d and then detached and reseeded for 2 h. The data indicates correlation of DINEs with suppression of MAPK-signaling pathways.