Table 1_A systematic analysis of gut microbiome characteristics in Chinese patients with gestational diabetes mellitus.docx

Objective<p>To systematically analyze the change pattern of core gut microbiota in Chinese gestational diabetes mellitus (GDM) patients and provide basis for GDM early microecological screening and probiotic intervention.</p>Methods<p>Databases including PubMed, web of science, CNKI, and Wanfang were searched to identify reports on the association between gut microbiota and GDM. A quantitative system evaluation was conducted to assess the changes in core gut microbiota levels (such as Bifidobacterium, Lactobacillus, etc.) in GDM.</p>Results<p>Totally, 31 studies involving 6,157 subjects were included.

Systematic analysis revealed that levels of Bifidobacterium (SMD = −2.47, 95%CI: −2.86 to −2.09) and Lactobacillus (SMD = −1.82, 95% CI: −2.04 to −1.60) in the GDM were significantly lower than those in controls; while Enterobacteriaceae (SMD = 1.75, 95% CI: 1.53 to 1.98) and Enterococcus (SMD = 1.18, 95%CI: 1.03 to 1.32) were significantly higher than those in non-GDM. Sensitivity analysis shows that the above findings are relatively robust.</p>Conclusion<p>GDM exhibit significant gut microbiota dysbiosis.