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Table · dataset · 2026

Characterization of Ionizable Lipid Membranes for Designing Bioactive Interface of Inorganic Particles

Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.1021/acs.langmuir.6c04968.s001

Magnetic nanoparticles and their composites are attractive candidates for novel photothermal therapy (PTT) agents in cancer treatment.

Description

However, the cellular uptake of these artificial particles remains insufficient because foreign materials are easily excreted from cells. Although lipid membrane coating offers a potential solution to this issue, the specific roles of lipid membrane properties, such as membrane fluidity, polarity, and pH responsive surface charge, remain unclear.

Herein, we investigated the physicochemical properties of lipid bilayers containing the ionizable cationic lipid, SM-102, and utilized them to functionalize photothermal magnetic composite particles (MCPs). Liposome characterization revealed that the incorporation of SM-102 slightly decreased the membrane fluidity. Coating the photothermal MCPs with SM-102 bilayers successfully imparted pH responsiveness.

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Consequently, these lipid-coated MCPs (L-MCPs) exhibited enhanced cellular uptake of particles in HeLa cells at acidic pH. Although both uncoated MCPs and L-MCPs were nontoxic under normal conditions, they exhibited cytotoxicity upon simultaneous exposure to NIR (808 nm) light and a direct current magnetic field (150 mT). Local temperature analyses revealed that L-MCP internalization led to elevated local temperatures in the mitochondria, whereas local heating in the lysosomes was reduced compared to pristine MCPs, indicating that coating with SM-102-containing lipid membranes can alter intracellular particle positioning.

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From keywords
Astronomy & Astrophysics · Biochemistry and cell biology · Biochemistry and cell biology · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Genetics · Genetics · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
Inferred from text
Cancer 75%
Provenance · 2 source records, 33 field assertions
SourceKeyLast seenRaw
figshareoai:figshare.com:article/3397858710 d agoJSON v1
Loughborough Research Repositoryoai:figshare.com:article/3397858710 d agoJSON v1
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