Supplementary file 1_Prior Parkinson’s disease diagnosis and subsequent self-reported psychological resilience in the UK Biobank.docx

Compared with the lowest BRS tertile, the OR was 0.63 (95% CI, 0.50–0.80) for the middle tertile and 0.43 (95% CI, 0.31–0.59) for the highest tertile (P for trend<0.001). Inverse associations were also observed for all six BRS items. The overall association was significant in restricted cubic spline analysis (p < 0.001), with no evidence of nonlinearity (P for nonlinearity = 0.314).

No statistically significant interactions were observed in subgroup analyses. Results were similar in inverse probability-weighted analyses, after additional adjustment for anxiety and depression, and after multiple imputation for missing covariates.</p>Conclusion<p>Prior Parkinson’s disease diagnosis was associated with lower subsequently assessed self-reported psychological resilience in the UK Biobank. Given the observational design, causality cannot be established.</p>