Aberrant neural network activation during reliving of autobiographical memories in adolescent depression

Investigating how adolescents relive positive autobiographical memories and activate the underlying neural networks could reveal mechanisms that drive such biases. This study investigated neural networks when reliving positive and neutral memories, and how neural activity is modulated by valence and vividness in adolescents with and without depression.

These data represent autobiographical memory characteristics as well as neural networks when reliving positive and neutral autobiographical memories in adolescents with and without depression, obtained via event-related independent component analysis (eICA). Adolescents (N = 69; n = 17 with depression) retrieved positive and neutral autobiographical memories. On a separate day, they relived these memories during fMRI scanning, and reported on pleasantness and vividness after reliving each memory.