Data · dataset · 2025
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
Listed in NASA Data Portal
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development.
Description
We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm triggering a STING-mediated innate immune response after replication stress and DNA damage.
Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing RAD51 is also implicated in the suppression of innate immunity. Thus our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling placing it at the hub of new interconnections between DNA replication DNA repair and immunity. Overall design Gene expression analysis of WT and sh RAD51 HT1080 cells was carried out before and after 1 Gy of high LET Fe particle radiation.
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-130 ↗
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/rad51-interconnects-between-dna-replication-dna-repair… ↗
landing page · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=90a03698-9db2-4e84-94d7-2c33294db… ↗
metadata API · from data nasa gov
Topics
- Inferred from text
- Cancer 75%
Related
- Possibly the same asRAD51 Interconnects Between DNA Replication DNA Repair and Immunity
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | 90a03698-9db2-4e84-94d7-2c33294db1dd | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · data nasa gov | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |