A Simple and Efficient Palladium Catalyst of Nitrogen-Based Ligand for Cu(I)- and Amine-Free Sonogashira Reaction

In the presence of 1% [PdCl 2 (NH 2 CH 2 COOH) 2 ] as catalyst, excellent catalytic activity towards the Sonogashira coupling of aryl iodides with terminal alkynes without using any additive such as Cu(I)-cocatalyst is observed in a mixture of water and acetone (3/3 mL) under air at 60 °C with NaOH as a base, giving products in good to excellent yields.