Omics · study · 2026
DMRT1 is required at two steps of ovarian differentiations in rabbits
Listed in NCBI GEO
The transcription factor DMRT1 is a key gene for testis differentiation and male fertility, but less is known about its potential involvement in ovarian differentiation.
Description
In mice, Dmrt1-/- females are fertile, even though they show a reduction of Stra8 expression. Using our DMRT1 mutant rabbit model, we analyzed ovarian differentiation when DMRT1 expression is abolished.
Firstly, we observed that during early gonadal development, DMRT1-/- gonads present a specific transcriptome different from control testes as well as control ovaries. Secondly, we assessed the infertility phenotype of mutant females. DMRT1 is highly expressed in germ cells until meiosis initiation, and its disruption leads to a downregulation of key genes involved in the meiotic process.
Read the rest (1 more)
ChIP-sequencing data highlighted that DMRT1 can bind these genes in the rabbit ovary. In addition to its role in testicular differentiation, we describe two roles of DMRT1 in ovarian differentiation. Our data suggested that DMRT1 can be considered as a gene necessary for human female fertility.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318019 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318019 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1416328 ncbi.nlm.nih.gov/bioproject/PRJNA1416328 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318019 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |