Table 1_WMRE2030: integrating wearable devices, multi-omics, and artificial intelligence–driven real-time feedback into a daily-scale closed-loop framework for a new era of precision exercise.docx

The framework emphasizes “the same architecture, different parameters, “ allowing sensors, omics inputs, decision thresholds, and levels of professional oversight to be adapted across clinical populations, the general population, and high-performance athletes. WMRE2030 should currently be regarded as a testable methodological roadmap rather than a validated autonomous prescription system. Future research should evaluate its incremental value through longitudinal, micro-randomized, and multicentre studies, while addressing interoperability, privacy, algorithmic transparency, safety brakes, cost-effectiveness, scalability, and equitable access.

By connecting biological interpretation with continuous sensing and adaptive decision support, WMRE2030 may provide a practical pathway toward more reliable and sustainable precision exercise.</p>