<p>-Reactive protein regression models.</p>

<p>Regression model of the internalizing disorders factor regressed on CRP in Panel <b>A</b> and a multiple regression model of the internalizing disorders factor regressed on CRP and IL-6 in Panel <b>B</b>. This demonstrates how significant relationships of CRP with psychiatric disorders may be better explained by IL-6. Factor loadings of the internalizing factor differ from those in the correlated factors model (<a href="plosgenetics.org/article/info:doi/10.1371/journal.pgen.1012328#pgen.1012328.g001" target="_blank">Fig 1</a>) because cross-loadings are dropped for the follow up regression models.

Single-headed arrows indicate regression relationships as modelled in genomic SEM and importantly do not imply expected or modeled directional relationships.</p>