New cytotoxic lignan glycosides from Phyllanthus glaucus

During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4- O -α-l-arabinopyranosyl-(1 → 3)-α-l-arabinopyranoside ( 1 ), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7- O -α-l-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside ( 2 ), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Müll.

Arg. In addition, 31 known compounds, including 19 lignan derivatives ( 3 – 21 ), four phenylpropanoids ( 22 – 25 ), seven simple phenolics ( 26 – 32 ) and one monoterpenoid ( 33 ) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations.