Consensus expression signatures for L1000 compounds

Starting with signature-level expression data from the L1000 project, we employ our pipeline (link below) to condense this information to consensus drug-level expression signatures. For a detailed overview of our approach, see the appended thinklab discussion link.

In brief, our approach has 3 steps. (1) Pool set of LINCS gold signatures corresponding to drug of interest. (2) Compute weights for each signature, based on their mean Spearman correlation values with all other signatures.