Omics · study · 2026
Adaption to chronic hypercapnia drives time- and site-dependent changes in brainstem cardiorespiratory nuclei.
Listed in NCBI GEO
Traditional mechanisms of respiratory neuroplasticity to not fully describe the temporal pattern of ventilatory adaptations to chronic hypercapnia.
Description
To gain insights into novel mechanisms that may underly such adaptations, we performed bulk-tissue RNA sequencing from three key brainstem cardiorespiratory site involved in acute chemosensitivity (the retrotrapezoid nucleus; RTN), respiratory rhythm generation (the ventral respiratory column, VRC), and peripheral information integration (the nucleus tractus solitarius, NTS) during three different time-points of acclimatization to chronic hypercapnia (3 hours (h), 24h, and 7 days (d)).
We hypothesized that chronic hypercapnia induces both time- and region-dependent transcriptional changes that may partially underly ventilatory and chemoreceptive adaptations.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299625 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299625 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1275764 ncbi.nlm.nih.gov/bioproject/PRJNA1275764 ↗
project · from NCBI GEO
- PubMed 42467500 pubmed.ncbi.nlm.nih.gov/42467500 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299625 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |