Data Sheet 1_Association of serum magnesium levels with the risk of spontaneous bacterial peritonitis and sepsis in hospitalized patients with cirrhosis: a retrospective cohort study.docx

Multivariable regression analysis showed that per 1-SD increase in serum magnesium, the risks of HA-SBP and sepsis decreased by 20.8% (odds ratio [OR] = 0.792, 95% confidence interval [CI]: 0.642–0.970, P = 0.026) and 35.5% (OR = 0.645, 95% CI: 0.464–0.883, P = 0.008), respectively. Compared with normomagnesemia, hypomagnesemia was associated with increased risks of HA-SBP (OR = 1.520, 95% CI: 1.009–2.286, P = 0.044) and sepsis (OR = 2.213, 95% CI: 1.189–4.177, P = 0.013).

Sensitivity analyses yielded consistent results. RCS analysis showed a linear inverse association between serum magnesium levels and the risks of HA-SBP and sepsis (both P for nonlinearity > 0.05). In addition, the areas under the receiver operating characteristic curves for serum magnesium in predicting HA-SBP and sepsis were 0.635 (95% CI: 0.583–0.686) and 0.688 (95% CI: 0.617–0.758), respectively.</p>Conclusions<p>Hypomagnesemia was associated with increased risks of HA-SBP and sepsis in patients with cirrhosis, and these findings should be further validated in prospective studies.</p>