Structure · collection · 2018
NLRP6 Induces Pyroptosis by Activation of Caspase-1 in Gingival Fibroblasts
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NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, has been reported to participate in inflammasome formation.
Description
Activation of inflammasome triggers a caspase-1–dependent programming cell death called pyroptosis. However, whether NLRP6 induces pyroptosis has not been investigated.
In this study, we showed that NLRP6 overexpression activated caspase-1 and gasdermin-D and then induced pyroptosis of human gingival fibroblasts, resulting in release of proinflammatory mediators interleukin (IL)–1β and IL-18. Moreover, NLRP6 was highly expressed in gingival tissue of periodontitis compared with healthy controls. Porphyromonas gingivalis , which is a commensal bacterium and has periodontopathic potential, induced pyroptosis of gingival fibroblasts by activation of NLRP6.
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Together, we, for the first time, identified that NLRP6 could induce pyroptosis of gingival fibroblasts by activation of caspase-1 and may play a role in periodontitis.
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- Repository landing page figshare.com/collections/NLRP6_Induces_Pyroptosis_by_Activation_of_Caspase-… ↗
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- DOI doi.org/10.25384/sage.c.4111019 ↗
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- CC BY 4.0 creativecommons.org/licenses/by/4.0 ↗
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- IsSupplementTo 10.1177/0022034518775036 doi.org/10.1177/0022034518775036 ↗
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Topics
- Stated by source
- Clinical medicine · Materials engineering
Related
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.25384/sage.c.4111019 | 15 d ago | JSON v1 |
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| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:materials-engineering | source · DataCite | connector:datacite@1.0.0 | |
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