Data · dataset · 2026
Refined Astragalus-Echinacea compound polysaccharides attenuate macrophage pyroptosis by dual modulation of the cAMP-PKA and TLR4-MyD88 signaling pathways
Listed in Teesside University Research Data Repository
Refined Astragalus-Echinacea compound polysaccharides attenuate macrophage pyroptosis by dual modulation of the cAMP-PKA and TLR4-MyD88 signaling pathways.
Description
Refined Astragalus-Echinacea compound polysaccharides attenuate macrophage pyroptosis by dual modulation of the cAMP-PKA and TLR4-MyD88 signaling pathways. 1. Morphological characterization of the refined Astragalus-Echinacea compound polysaccharides (C-APS), including ultrastructural observation by electron microscopy and determination of average molecular weight by atomic force microscopy. 2.
Evaluation of the biosafety profile of refined Astragalus-Echinacea compound polysaccharides in J774A.1 macrophages. Pyroptosis was induced in J774A.1 macrophages using lipopolysaccharide (LPS) and adenosine triphosphate (ATP). The anti-pyroptotic effect of C-APS was assessed by Hoechst 33342/PI staining and ELISA detection of caspase-1, caspase-3, IL-1β, and IL-18 levels.
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Mechanistic studies were conducted using pathway-specific inhibitors (MDL12330A, H89, RDR02308, TJ-M2010-5). The data are saved in Excel format and are directly accessible. Unauthorized use is prohibited without the explicit permission of the owner.
Links
Where it is published
- DOI doi.org/10.17632/2jjj4t4zwf.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Agronomy · Earth & Environmental Science
- Inferred from text
- Microscopy 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/2jjj4t4zwf.1 | 12 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].anzsrc:field:300403 | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['Agronomy'] |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:microscopy | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |