Hyaluronic acid/PEO electrospun tube reduces tendon adhesion to levels comparable to native tendons – an in vitro and in vivo study

As hyaluronic acid/polyethylene oxide was the first time added to DegraPol electrospun scaffolds, material properties were analyzed with SEM, Fourier-transformed infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Water Contact Angle (WCA), and by testing the mechanical qualities.

Tubes were applied in a full laceration rabbit Achilles tendon and three weeks after implantation, the adhesion extent of the extracted Achilles tendons was determined using Picrosirius Red staining.