Effect of anti-retroviral regimen on proximal tubular function in Zambian adolescents and young adults living with HIV

These were either on Tenofovir or Abacavir-based antiretroviral regimen . SmartCare, a national HIV electronic medical database, was used to select eligible participants between May 2018 and March 2019 using a checklist to verify eligibility.

All participants were aged between 10 and 24 years who had received ART for a minimum of 12 months and had a documented normal estimated glomerular filtration rate (eGFR) at initiation of the current antiretroviral regimen. Written informed consent and/or assent for participation in this study were obtained from each participant and/or parent or guardian. The study adhered to the declaration of Helsinki