Effect of ALA on Preventing Diabetic Peripheral Neuropathy in Rats through Mitochondrial Axonal Transport

The number of diabetic peripheral neuropathy rising in the world, has brought a lot of people suffering. Its treatment has also become a serious problem, and at present, there are no approved treatments or drugs for Diabetic Peripheral Neuropathy (DPN).

Mitochondria are a source of cellular energy, and the survival of peripheral nerve axon terminals is largely dependent on energy support. Because neurons are sites of high energy demands, with their unique polarized structure, mitochondrial transport is required to maintain energy homeostasis throughout the cell, especially in distal axons. So it is possible that mitochondrial transport function abate is one of the mechanisms of DPN.