Data on the correlation between hemostatic parameters before treatment start, and markers of fibrinolysis during treatment in patients with acute pulmonary embolism, undergoing ultrasound-assisted catheter-directed thrombolysis

We recently demonstrated, that various fibrinolytic parameters, including the plasma-based inducible plasmin-antiplasmin (plap) complex, as well as viscoelastic parameters, predict the individual treatment response in patients with intermediate- or high-risk pulmonary embolism (PE), treated with ultrasound-assisted catheter-directed thrombolysis (USAT).

Markers of fibrinolysis and coagulation were assessed before the start of treatment (t0) and during the 10 - 15-hour infusion of recombinant tissue-type plasminogen activator (rt-PA) (t6). While we have already provided evidence of the predictive value of the assessed parameters for efficacy outcomes, in this article we present data on the correlation between these predictive markers and the endogenous fibrinolytic response during USAT.