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Data · dataset · 2026

De-identified dataset and analysis code for: Nonlinear Association Between Fever-to-IVIG Interval and Clinical Outcomes in Kawasaki Disease — A Retrospective Cohort Study of 6,921 Children

Listed in ScienceDB

This dataset supports the article "Nonlinear Association Between Fever-to-IVIG Interval and Clinical Outcomes in Kawasaki Disease: A Retrospective Cohort Study of 6,921 Children" (submitted to BMC Medicine).

Description

It comprises a de-identified, patient-level analytical dataset from a single-center retrospective cohort of 6,921 children diagnosed with Kawasaki disease (KD) and treated with initial intravenous immunoglobulin (IVIG, 2 g/kg) at Wuhan Children's Hospital between December 2012 and November 2025.

The study investigates the nonlinear (U-shaped) association between the fever-to-IVIG interval and clinical outcomes, including IVIG resistance, coronary artery dilation (maximum Z-score >2.0), and aneurysm-level coronary involvement.The dataset contains one record per patient (6,921 rows × 44 variables), covering demographics (age in integer months, sex), principal clinical features, the primary exposure (fever-to-IVIG interval, days), timing variables, first-available pre-IVIG laboratory values (complete blood count, inflammatory markers, biochemistry, lymphocyte subsets, immunoglobulins, and complement), and four coronary and treatment outcome variables.

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Rigorous de-identification was applied: all direct identifiers and exact dates were removed; age is released in integer months; calendar year is released only as era categories; row order was randomly permuted; and extreme timing values were top-coded at 21 days. A full data dictionary, missing-data summary, de-identification protocol, and residual re-identification risk assessment are provided in the accompanying README file.An executable Python script (reproduce_analyses.py) is included, which reproduces all primary and sensitivity analyses reported in the article — including group comparisons (reference: 5–7 days), multivariable logistic regression with standardized covariates, nonlinearity likelihood-ratio tests, era-stratified analyses (2012–2018 vs. 2019–2025), and a sensitivity analysis restricted to complete KD — using only pandas, numpy, scipy, and statsmodels.Access: Controlled access under a data-use agreement (non-commercial academic research only; no re-identification attempts; no onward redistribution).

Requests should be sent to the corresponding author and will be acknowledged within 30 days.Ethics: Approved by the Institutional Review Board of Wuhan Children's Hospital (2024R034-E01), with a waiver of informed consent for de-identified retrospective data.

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Where it is published

Catalogue records · 1

Topics

Inferred from text
Disease 75% · Longitudinal study 65%
Provenance · 1 source records, 13 field assertions
SourceKeyLast seenRaw
ScienceDB10.57760/sciencedb.4397010 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · scidb cnconnector:scidb_cn@1.0.0
concepts[disease].local:disease:diseaseenrichment · scidb cnkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:earth-environmentalmapping · scidb cnconnector:scidb_cn@1.0.0
concepts[field].local:field:engineeringmapping · scidb cnconnector:scidb_cn@1.0.0
concepts[field].local:field:humanitiesmapping · scidb cnconnector:scidb_cn@1.0.0
concepts[field].local:field:life-sciencesmapping · scidb cnconnector:scidb_cn@1.0.0
concepts[field].local:field:medicine-healthmapping · scidb cnconnector:scidb_cn@1.0.0
concepts[field].local:field:social-sciencemapping · scidb cnconnector:scidb_cn@1.0.0
concepts[method].local:method:longitudinal-studyenrichment · scidb cnkeyword-concept-rules@1.0.0title+description (65%)
descriptionsource · scidb cnconnector:scidb_cn@1.0.0/metadata/dc/description
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publication_datesource · scidb cnconnector:scidb_cn@1.0.0
titlesource · scidb cnconnector:scidb_cn@1.0.0/metadata/dc/title