Data · dataset · 2026
De-identified dataset and analysis code for: Nonlinear Association Between Fever-to-IVIG Interval and Clinical Outcomes in Kawasaki Disease — A Retrospective Cohort Study of 6,921 Children
Listed in ScienceDB
This dataset supports the article "Nonlinear Association Between Fever-to-IVIG Interval and Clinical Outcomes in Kawasaki Disease: A Retrospective Cohort Study of 6,921 Children" (submitted to BMC Medicine).
Description
It comprises a de-identified, patient-level analytical dataset from a single-center retrospective cohort of 6,921 children diagnosed with Kawasaki disease (KD) and treated with initial intravenous immunoglobulin (IVIG, 2 g/kg) at Wuhan Children's Hospital between December 2012 and November 2025.
The study investigates the nonlinear (U-shaped) association between the fever-to-IVIG interval and clinical outcomes, including IVIG resistance, coronary artery dilation (maximum Z-score >2.0), and aneurysm-level coronary involvement.The dataset contains one record per patient (6,921 rows × 44 variables), covering demographics (age in integer months, sex), principal clinical features, the primary exposure (fever-to-IVIG interval, days), timing variables, first-available pre-IVIG laboratory values (complete blood count, inflammatory markers, biochemistry, lymphocyte subsets, immunoglobulins, and complement), and four coronary and treatment outcome variables.
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Rigorous de-identification was applied: all direct identifiers and exact dates were removed; age is released in integer months; calendar year is released only as era categories; row order was randomly permuted; and extreme timing values were top-coded at 21 days. A full data dictionary, missing-data summary, de-identification protocol, and residual re-identification risk assessment are provided in the accompanying README file.An executable Python script (reproduce_analyses.py) is included, which reproduces all primary and sensitivity analyses reported in the article — including group comparisons (reference: 5–7 days), multivariable logistic regression with standardized covariates, nonlinearity likelihood-ratio tests, era-stratified analyses (2012–2018 vs. 2019–2025), and a sensitivity analysis restricted to complete KD — using only pandas, numpy, scipy, and statsmodels.Access: Controlled access under a data-use agreement (non-commercial academic research only; no re-identification attempts; no onward redistribution).
Requests should be sent to the corresponding author and will be acknowledged within 30 days.Ethics: Approved by the Institutional Review Board of Wuhan Children's Hospital (2024R034-E01), with a waiver of informed consent for de-identified retrospective data.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.43970 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Disease 75% · Longitudinal study 65%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.43970 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |