Omics · study · 2026
Transcriptomics reveals orchestration of larval and juvenile development and metamorphosis in Southern Flounder Paralichthys lethostigma (reanalysis of GSE307589)
Listed in NCBI GEO
Developmental transitions involve changes in the genetic programs governing molecular processes.
Description
Characterizing these genetic programs gives us insight into how genes work to orchestrate developmental transitions in morphology, physiology, or even behavior. One fascinating developmental transition, metamorphosis, bridges larval and juvenile periods.
Southern Flounder, a flatfish, is an ideal model system to investigate these developmental states due to dramatic phenotypic changes during metamorphosis. Here, we use transcriptomics to investigate how genetic programs orchestrate larval development, metamorphosis, and juvenile development in Southern Flounder. Our analysis of Southern Flounder transcriptomes comprehensively describes distinct larval and juvenile genetic programs that overlap during metamorphosis.
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We also describe a third genetic program that peaks during metamorphosis. These results provide insight into molecular orchestration of flatfish and teleost metamorphosis and more generally into how the timing of genetic programs orchestrates metamorphosis. We also propose that these program trajectories can be used to pinpoint timing of metamorphosis in animals with less phenotypically distinct larval and juvenile forms.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348474 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348474 ↗
landing page · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Third-party reanalysis
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE348474 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:third-party-reanalysis | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |