<p>Matched-null calibration of single-cell perturbation scores.</p>

Each observed score was compared with 200 control genes matched on mean log-normalized expression and wild-type weighted out-degree within the corresponding 600- or 601-gene network stratum. Asterisks indicate global FDR < 0.05, and NE indicates that no evaluable result was obtained.

(B) Observed perturbation scores and corresponding matched-null means and 2.5th–97.5th percentile intervals. (C) Null-calibrated Z scores and one-sided empirical P values. Triangles indicate pairs with global FDR < 0.05.