Discovery and in vitro evaluation of the peptide, QUB-2667, from the frog skin secretion of Amolops Loloensis

Nature has been recognised as the richest source of novel treatments. Numerous pharmacological and antimicrobial peptides (AMPs) have been discovered and effectively extracted from amphibian skin and related secretions.

Moreover, some of these peptides have been identified as remarkable new therapeutic candidates. <br><br>The investigation of an AMP from the protective skin secretions of Amolops loloensis was the main objective of this work. Following the identification of the precursor structure by molecular cloning, the amino acid sequence of the mature peptide (FLPMLAGLAANFLPELFCKITKKC) was deduced from the results of an NCBI BLAST search and a CLUSTAL OMEGA sequence alignment.<br><br>After the peptide was produced by solid phase peptide synthesis, it was tested in many biological experiments.