Data · dataset · 2026
The discovery, identification, and bioactivity screening of peptide, QUB-2335, from skin secretion of the frog, Amolops hainanensis
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32633343.v1
Due to the resistance of antibiotics, the research of antimicrobial peptides has become a hot topic.
Description
In this study, a novel peptide named, QUB-2335, was identified and characterised from the skin secretion of the frog (Amolops hainanensis) by the strategy of ‘shotgun’ cloning. The deduced mature peptide sequence was confirmed as: FALGAVTKRLPSLFCLITRKC.
QUB-2335 showed a broad-spectrum antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and yeast. The result of QUB-2335 towards E. coli and S. aureus in MIC assays, were 4 μM and 4 μM, and in MBC assays, were 16 μM and 8 μM. Also, the MIC/MBC values of QUB-2335 against C. albicans, were is 64 μM and 128 μM. The haemolysis assay results showed that the QUB-2335 had only 27.1% haemolysis at the concentration of 256μM. The anticancer cell assay revealed a potent inhibition of cancer cell proliferation.
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At a concentration of 10-4 M, a significant impact of QUB-2335 was observed. These experiments on QUB-2335 revealed antibacterial and anticancer cell activities with potential of low side effects. Thus, this peptide has some value and potential to become a clinical drug after further research and modification.<br><br><i>Thesis embargoed until 31st December 2027 </i>
Links
Where it is published
- DOI doi.org/10.17034/32633343.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Cancer 75%
Provenance · 4 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32633343 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32633343 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32633343 | 11 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32633343 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |